Anti-BAD (Phospho-Ser136)
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
Product Specifications
CAS Number
9007-83-4
Reactivity
Human,Mouse,Rat
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from mouse BAD around the phosphorylation site of serine136 (S-R-S[P]-A-P).
Clonality
Polyclonal
Type
Antibodies-Polyclonal
Applications
IHC
Concentration
100ug/100ul
Purity
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Shipping Conditions
Ice Pack
Storage Conditions
Fragment
IgG
Specificity
BAD (phospho-Ser136) antibody detects endogenous levels of BAD only when phosphorylated at Serine 136.
Applications Notes
• Routine PCR amplification of DNA templates up to 6 kb • Suitable for a wide range of PCR assays • TA cloning
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