Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

(S,R,S)-AHPC-PEG2-N3

Product Specifications

UNSPSC Description

(S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Target Antigen

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/E3_ligase_Ligand-Linker_Conjugates_13.html

Purity

99.74

Solubility

DMSO : 125 mg/mL (ultrasonic)|Ethanol : 50 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCN=[N+]=[N-]

Molecular Weight

601.72

References & Citations

[1]Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, stored under nitrogen)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-103599/S-R-S-AHPC-PEG2-N3-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-103599/S-R-S-AHPC-PEG2-N3-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

2010159-45-0

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

SLC3A1 AAV Vector (Human) (CMV)
44192101 1 μg

SLC3A1 AAV Vector (Human) (CMV)

Ask
View Details
Carbonic Anhydrase IX (CA9) Magnetic Luminex Assay Kit
LKU600982 96 Tests

Carbonic Anhydrase IX (CA9) Magnetic Luminex Assay Kit

Ask
View Details
Human PI4KB (NM_001198773) AAV Particle
RC230877A1V 250 µL

Human PI4KB (NM_001198773) AAV Particle

Ask
View Details
Anti-Nucleophosmin (Acute Myeloid Leukemia Marker)(NPM1/1902), CF405S conjugate
BNC041902-500 500 µL

Anti-Nucleophosmin (Acute Myeloid Leukemia Marker)(NPM1/1902), CF405S conjugate

Ask
View Details
Shc1 Mouse Gene Knockout Kit (CRISPR)
KN515739 1 Kit

Shc1 Mouse Gene Knockout Kit (CRISPR)

Ask
View Details