6-O-Caffeoylarbutin

6-O-Caffeoylarbutin (Robustaside B) possesses antioxidant activity[1]. 6-O-Caffeoylarbutin ameliorates neurological functions and deficits in ischemic mice.

Product Specifications

CAS Number

[136172-60-6]

Product Name Alternative

Robustaside B

UNSPSC

12352005

Target

PI3K; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/6-o-caffeoylarbutin.html

Purity

99.47

Solubility

10 mM in DMSO

Smiles

OC(C=C1/C=C/C(OC[C@H]([C@H]([C@@H]([C@H]2O)O)O)O[C@H]2OC3=CC=C(C=C3)O)=O)=C(C=C1)O

Molecular Formula

C21H22O10

Molecular Weight

434.39

References & Citations

[1]Rahmat A Adisa, et al. Robustaside B and para‑hydroxyphenol: phenolic and antioxidant compounds purified from Cnestis ferruginea D.C induced membrane permeability transition in rat liver mitochondria. Mol Med Rep. 2013 Nov;8 (5) :1493-8.|[2]Shi ZQ, Wen X, Wu XR, et al. 6'-O-caffeoylarbutin of Vaccinium dunalianum alleviated ischemic stroke through the PI3K/AKT/NF-κB pathway. Phytomedicine. 2025;139:156505. |[3]Wang Y, Wang Y, Zhao T, et al. 6'-O-caffeoylarbutin attenuates D-galactose-induced brain and liver damage in aging mice via regulating SIRT1/NF-κB pathway. Phytomedicine. 2025;141:156710. |[4]Wang YP, Wang YD, Liu YP, et al. 6'-O-Caffeoylarbutin from Que Zui tea ameliorates acetaminophen-induced liver injury via enhancing antioxidant ability and regulating the PI3K signaling pathway. Food Funct. 2022;13 (9) :5299-5316.