5-HT1AR agonist 2
5-HT1AR agonist 2 (Compound 4f) is a 5-HT1A receptor agonist (Ki: 10.0 nM) . 5-HT1AR agonist 2 also binds to the SERT, D2 receptor and 5-HT6 receptor (Ki: SERT, 2.8 nM; D2, 23 nM; 5-HT6, 192 nM) . 5-HT1AR agonist 2 is stabilized in microsomes and induces hypothermia in mice[1].
Product Specifications
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor; Serotonin Transporter
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/5-ht1ar-agonist-2.html
Smiles
N#CC1=CC2=C(NC=C2C3=CCN(CCCCN4C(C(C5=CNC6=C5C=C(OC)C=C6)CC4=O)=O)CC3)C=C1
Molecular Formula
C31H31N5O3
Molecular Weight
521.61
References & Citations
[1]Siwek, et al. Synthesis and biological evaluation of novel 3- (5-substituted-1H-indol-3-yl) pyrrolidine-2,5-dione derivatives with a dual affinity for serotonin 5-HT1A receptor and SERT. Bioorganic chemistry, 2023, 141, 106903.|[2]Siwek, et al. Synthesis and biological evaluation of novel 3- (5-substituted-1H-indol-3-yl) pyrrolidine-2,5-dione derivatives with a dual affinity for serotonin 5-HT1A receptor and SERT. Bioorganic chemistry, 2023, 141, 106903.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT6 Receptor; D2 Receptor; mLAG-3; MUC2
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