5-HT1AR agonist 2

5-HT1AR agonist 2 (Compound 4f) is a 5-HT1A receptor agonist (Ki: 10.0 nM) . 5-HT1AR agonist 2 also binds to the SERT, D2 receptor and 5-HT6 receptor (Ki: SERT, 2.8 nM; D2, 23 nM; 5-HT6, 192 nM) . 5-HT1AR agonist 2 is stabilized in microsomes and induces hypothermia in mice[1].

Product Specifications

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor; Serotonin Transporter

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5-ht1ar-agonist-2.html

Smiles

N#CC1=CC2=C(NC=C2C3=CCN(CCCCN4C(C(C5=CNC6=C5C=C(OC)C=C6)CC4=O)=O)CC3)C=C1

Molecular Formula

C31H31N5O3

Molecular Weight

521.61

References & Citations

[1]Siwek, et al. Synthesis and biological evaluation of novel 3- (5-substituted-1H-indol-3-yl) pyrrolidine-2,5-dione derivatives with a dual affinity for serotonin 5-HT1A receptor and SERT. Bioorganic chemistry, 2023, 141, 106903.|[2]Siwek, et al. Synthesis and biological evaluation of novel 3- (5-substituted-1H-indol-3-yl) pyrrolidine-2,5-dione derivatives with a dual affinity for serotonin 5-HT1A receptor and SERT. Bioorganic chemistry, 2023, 141, 106903.