1- (1-Naphthyl) piperazine (hydrochloride)

1-1-Naphthylpiperazine hydrochloride (1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride) is a serotonergic derivative of quipazine, which is both an agonist for 5-HT1A receptor and an antagonist for 5-HT2A receptor. 1-1-Naphthylpiperazine hydrochloride induces cell apoptosis. 1-1-Naphthylpiperazine hydrochloride prevents the immunosuppression and photocarcinogenesis[1].

Product Specifications

CAS Number

[104113-71-5]

Product Name Alternative

1-NP (hydrochloride) ; 1-Naphthylpiperazine (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

5-HT Receptor; Apoptosis

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/1-1-naphthyl-piperazine-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

C12=C(C=CC=C2N3CCNCC3)C=CC=C1.Cl

Molecular Formula

C14H17ClN2

Molecular Weight

248.75

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Menezes AC, et al., Cytotoxic effect of the serotonergic drug 1- (1-Naphthyl) piperazine against melanoma cells. Toxicol In Vitro. 2018 Mar;47:72-78.|[2]Sreevidya CS, et al., Agents that reverse UV-Induced immune suppression and photocarcinogenesis affect DNA repair. J Invest Dermatol. 2010 May;130 (5) :1428-37.