Recombinant Rat IL17
Interleukin-17 (IL-17 or IL-17A) is the founder member of the IL-17 cytokine family, which shares 50% homology with IL-17F. IL-17 cytokines are produced by T helper (Th)17 cells, gamma delta T cells, and other immune cells. IL-17A and IL-17F form homodimers and heterodimers as functional ligands. IL-17 cytokines bind to 2 receptors, IL-17RA and IL-17RC. IL-17RC forms a receptor heterodimer with IL-17RA. The receptor heterodimer is preferred by IL-17 ligands , thus, either IL-17RA knockout (KO) or IL- 17RC KO completely abolishes IL-17 signaling. IL-17A and IL-17F are key proinflammatory cytokines involved in many inflammatory and autoimmune diseases.
Product Specifications
Gene Name
IL17
Gene Aliases
Interleukin-17A, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8<br/>Recombinant Rat Interleukin-17 (IL17)
Gene ID
301289
Accession Number
Q61453
Organism
Rat
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
Function
The activity was measured by the ability to induce IL-6 secretion in murine 3T3 cell assay.
Molecular Weight
16
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Recombinant Rat Interleukin-17 was lyophilized from a 0.2 μm filtered PBS solution pH 7.5.
CAS Number
9000-83-3
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