Recombinant Mouse IL33
IL-33, a member of the IL-1 family, signals via a heterodimeric receptor complex consisting of ST2 and IL-1R accessory protein and triggers the activation of NF-B and all three MAPKs: p38, ERK1/2, and JNK1/2 in mast cells. IL-33 is expressed in multiple tissues and by several cell types such as dermal fibroblasts and small airway epithelial and bronchial smooth muscle cells. IL-33 activated IL-1-like signaling responses in mast cells and enhanced IL-5 and IL-13 production from murine Th2-polarized splenocytes. Moreover, it was found that both human and murine mast cells when stimulated in vitro with IL-33 produced a wide spectrum of cytokines and chemokines . In addition, IL-33 enhanced IL-4-driven Th2 cell responses and acted as a selective chemoattractant for Th2 cell recruitment.
Product Specifications
CAS Number
9000-83-3
Gene Name
IL33
Gene Aliases
IL-33<br/>Recombinant Mouse Interleukin-33 (IL33)
Gene ID
77125
Accession Number
Q8BVZ5
Organism
Mouse
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
Function
The ED(50) was determined by the dose-dependent proliferation of murine D10S cells is ≤ 0.3 ng/mL.
Molecular Weight
18
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Recombinant Interleukin-33 was lyophilized from a 0.2 μm filtered PBS solution pH 7.5.
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