Recombinant Mouse IL11
IL-11 is secreted by bone marrow stromal cells (fibroblasts) and is produced also by a number of mesenchymal cells. The IL-11 receptor (alpha chain) utilizes gp130 as its signal transducer, which is also a component of other cytokine receptors. The alpha chain of the IL-11 receptor has been identified independently as Etl2. IL-11 promotes primary and secondary immune responses in vitro and in vivo and modulates antigen-specific antibody reactions. IL-11 promotes the proliferation of IL-6 dependent plasmacytoma cell lines in the presence of neutralizing IL6 antibodies. IL-11 also stimulates the T cell dependent development of IgG-secreting B cells in spleen cell cultures. IL-11 inhibits the differentiation of pre-adipocytes. It induces the synthesis of some acute phase proteins by hepatocytes.
Product Specifications
Gene Name
IL11
Gene Aliases
IL-11<br/>Recombinant Mouse Interleukin-11 (IL11)
Gene ID
16156
Accession Number
P47873
Organism
Mouse
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
Function
The ED(50) was determined by the dose-dependent proliferation of LLC1 cells and was found to be <0.5ng/mL.
Molecular Weight
19
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Recombinant mouse IL-11 was lyophilized from a 0.2 μm filtered PBS solution.
CAS Number
9000-83-3
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