Recombinant Mouse IGF1
The Insulin Like Growth Factors, or somatomedins, belong to the Insulin gene family, members of which are insulin and relaxin. The IGFs play similar a similar role to insulin with regards to the regulation of glucose uptake and glycogen metabolism. Additionally IGF1 plays an essential role in mediating many of the effects of growth hormone. IGFs are produced first as inactive precursors, and undergo proteolysis to become active. Circulating IGF1 is produced by hepatocytes whereas local IGF1 is produced in a variety of other tissues where it exhibits paracrine effects. Mouse IGF1 shares 94% and 98% amino acid sequence identity with human and rat IGF1 respectively. Recombinant Mouse IGF1 is a globular, 7.9 kDa protein which contains 3 native disulfide bonds.
Product Specifications
Gene Name
IGF1
Gene Aliases
IGF-I, Mechano growth factor, MGF, Somatomedin-C, IBP1, Recombinant Mouse Insulin Like Growth Factor-I (IGF1)
Accession Number
P05017
Organism
Mouse
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method
Purity
>95% as determined by SDS-PAGE
Solubility
A quick spin of the vial followed by reconstitution in sterile distilled water to a concentration not less than 0.1 mg/mL.
Function
The ED50 of Recombinant Mouse IGF1 as found by dose dependent proliferation of mouse 3T3 cells was found to be <0.1 ng/ml.
Molecular Weight
7.9
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 micron filtered solution in Phosphate buffer and NaCl
CAS Number
9000-83-3
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