Recombinant Mouse G-CSF (CSF3)
Granulocyte colony-stimulating factor (G-CSF) is a growth factor and cytokine belonging to the IL-6 family of interleukins. It is produced by a variety of cells such as: endothelial cells, bone marrow stroma, macrophages, fibroblasts, and other immune cells in response to endotoxin activation. G-CSF stimulates the bone marrow to stimulate the survival, proliferation and differentiation of progenitor cells to mature neutrophils while enhancing its activities. It indirectly mobilizes stem cells by downregulating the expression of CXCL12 on marrow osteoblasts and releases neutrophil and monocyte proteolytic enzymes. Mouse G-CSF affects mouse skeletal muscle development by activating proliferation of myoblasts. Human and murine G-CSF shares a 73% amino acid identity and is cross-reactive.
Product Specifications
CAS Number
9000-83-3
Gene Name
CSF3
Gene Aliases
Granulocyte colony-stimulating factor
Gene ID
12985
Accession Number
P09920
Organism
Mouse
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method
Purity
>95% as determined by SDS-PAGE
Solubility
Reconstitute in sterile deionized water at 100 µg/mL
Function
The ED50 was 10.0-60.0 pg/mL as determined by a cell proliferation assay
Molecular Weight
19.2
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 µm filtered solution in PBS
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