Recombinant Human WISP3

WNT1-inducible-signaling pathway protein 3 (WISP3) is a member of the CCN family of cysteine-rich, glycosylated signalling proteins that mediate several developmental processes, and a member of the WNT1 inducible signalling pathway (WISP) subfamily. Members of this family are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain (IGFBP), von Willebrand factor type C (VWFC) domain, thrombospondin type-1 repeat (TSP type-1) domain, and C-terminal cystine knot-like (CTCK) domain. WISP3 is expressed in mature and fetal kidneys, testis, and in lower levels in the ovary, placenta, prostate, and small intestine. It is necessary for the growth of postnatal skeleton and cartilage homeostasis.

Product Specifications

CAS Number

9000-83-3

Gene Name

WISP3

Gene Aliases

WNT1-inducible-signaling pathway protein 3

Gene ID

8838

Accession Number

O95389

Organism

Human

Source

E. coli

Concentration

<1.0 EU/μg of recombinant protein as determined by the LAL method

Purity

>95% as determined by SDS-PAGE

Function

The ED(50) was determined by the dose-dependent proliferation of MCF7 cells and was found to be <0.5ng/mL.

Molecular Weight

37.1

Shipping Conditions

Ambient Temperature

Storage Conditions

The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.