Recombinant Human TWEAK Receptor (TNFRSF12A)

Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) is the receptor for TNFSD12/TWEAK and is the smallest member of the TNF receptor superfamily. It is composed of a signal peptide, an extracellular domain, a membrane-anchoring domain, and a cytoplasmic “death” domain, which can activate a cell’s apoptotic mechanisms. It also promotes endothelial cell proliferation and angiogenesis, and modulates cellular adhesion to matrix proteins. TNFRSF12A expression can be found in the spleen, thymus, small intestine, and colon, and can be activated by membrane-anchored or soluble versions of TWEAK.

Product Specifications

CAS Number

9000-83-3

Gene Name

TNFRSF12A

Gene Aliases

Fibroblast growth factor-inducible immediate-early response protein 14, Tweak-receptor, CD-antigen: CD266

Gene ID

51330

Accession Number

Q9NP84

Organism

Human

Source

E. coli

Concentration

<1.0 EU/μg of recombinant protein as determined by the LAL method

Purity

>95% as determined by SDS-PAGE

Function

The ED(50) was determined by the dose-dependent proliferation of human umbilical vein endothelial cells and was found to be <0.2ng/mL.

Molecular Weight

5.6

Shipping Conditions

Ambient Temperature

Storage Conditions

The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.