Recombinant Human TWEAK (TNFSF12)
TWEAK is a TNF superfamily transmembrane protein which is expressed in many different cells and tissues, such as the heart, spleen and small intestine. Two different receptors have been identified that bind TWEAK; the Death Receptor 3 (DR3) and the TWEAK Receptor (TWEAKR). While DR3 is expressed mainly in tissues that have high concentration of lymphocytes, the mitogen-inducible TWEAKR is has been shown to be expressed in fibroblasts, hepetocellular carcinomas and endothelial cells. Recombinant human TWEAK comprises the TNF homologous (secreted region) of TWEAK.
Product Specifications
CAS Number
9000-83-3
Gene Name
TNFSF12
Gene Aliases
Gene ID
407977
Accession Number
O43508
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
Reconstitute at 0.1mg/ml/mL in sterile PBS containing at least 0.1% human or bovine serum albumin
Molecular Weight
17.2
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein
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