Recombinant Human TRAIL (TNFSF10)
A cytotoxic protein, TRAIL initiates apoptosis in tumor cells by binding the death-signalling receptors; DR4 and DR5. In its active conformation, TRAIL forms homotrimers. TRAIL transcripts have been shown to be constitutively expressed in a variety of human tissues. There are five known TRAIL receptors: two which transduce apoptotic signals, two which function as decoys to block TRAIL-induced apoptosis and osteoptotegrin.
Product Specifications
CAS Number
9000-83-3
Gene Name
TNFSF10
Gene Aliases
Gene ID
8743
Accession Number
P50591
Organism
Human
Source
E. coli
Concentration
< 1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
Reconstitute at 20 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin
Function
N.A.
Molecular Weight
19.5
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
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