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Recombinant Human TNFRSF1B

TNFRSF1B is a single-pass type-1 transmembrane protein that functions as a receptor with high affinity for TNFSF2/TNF-alpha . It has been shown that signaling through this receptor regulates various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. Recombinant human TNFRSF1B comprises the extracellular domain (ligand binding) of the TNFRII protein.

Product Specifications

Gene Name

TNFRSF1B

Gene Aliases

sTNF Receptor Type II, sTNFRII, TNFRSF1B, Tumor necrosis factor receptor 2, TNF-RII, TNF-R2, TNFR-II, TNFR75, TNFR80, p80 TNF-alpha receptor<br/>Recombinant Human Tumor Necrosis Factor Receptor Superfamily Member 1B (TNFRSF1B)

Gene ID

7133

Accession Number

P20333

Organism

Human

Source

E. coli

Concentration

< 1.0 EU/μg of recombinant protein as determined by the LAL method.

Purity

>95% as determined by SDS-PAGE

Solubility

Reconstitute at 0.1mg/mL in sterile PBS.

Function

The ED(50) was determined by the dose-dependent proliferation of Immortalized human renal proximal tubule cells and was found to be &lt;0.05ng/mL.

Molecular Weight

19

Shipping Conditions

Ambient Temperature

Storage Conditions

The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Appearance

Lyophilized Powder

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS.

CAS Number

9000-83-3

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