Recombinant Human TNFRSF10B
TNFRSF10B is a member of the TNFR superfamily and is a cell surface receptor that is involved in apoptosis. It contains an intracellular death domain and can be activated by binding to either membrane-anchored or soluble TRAIL/Apo2L. Diseases associated with TNFRSF10B include squamous cell carcinoma, head and neck and oral cavity cancer. Among its related pathways are Akt Signaling and Akt Signaling. It is closely related to TRAIL R1/DR4, sharing 55% amino acid sequence identity.
Product Specifications
CAS Number
9000-83-3
Gene Name
TNFRSF10B
Gene Aliases
Gene ID
8795
Accession Number
O14763
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
Function
The ED(50) was determined by the dose-dependent proliferation of human umbilical vein endothelial cells and was found to be <0.2ng/mL.
Molecular Weight
15
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a solution in PBS (pH 7.4) with 5% Mannitol, 5% Trehalose and 0.02% Tween 80.
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