Recombinant Human sCD23 (FCER2)

CD23 is a calcium dependent transmembrane glycoprotein which is expressed in many cell types. The cytoplasmic region of the protein has two isoforms â€“ the 'a' isoform that participates in IgE-regulated endocytosis, and the 'b' isoform, which is involved in IgE-regulated phagocytosis. It has been found that there are at least four soluble forms of the CD23 protein (sCD23) all of which are produced by the activity of metallo/cysteine proteases. In addition to binding IgE, sCD23 have been shown to promote the activation and differentiation of B-cells and stimulate the release of pro-inflammatory cytokines from monocytes.

Product Specifications

Gene Name

FCER2

Gene Aliases

Low affinity immunoglobulin epsilon Fc receptor, BLAST-2, Fc-epsilon-RII, Immunoglobulin E-binding factor, Lymphocyte IgE receptor, CD23, B cell differentiation antigen<br/>Recombinant Human C-type Lectin Domain Family 4 Member J (FCER2)

Gene ID

2208

Accession Number

P06734

Organism

Human

Source

E. coli

Concentration

<1.0 EU/μg of recombinant protein as determined by the LAL method.

Purity

>95% as determined by SDS-PAGE

Solubility

Reconstitute at 100 Î¼g/mL in sterile PBS

Function

Measured by its ability to bind in a functional ELISA. Immobilized rhCD23 at 2 Âµg/mL (100 ÂµL/well) can bind human IgE with a linear range of 0.015Â1 Âµg/mL.

Molecular Weight

19.5

Shipping Conditions

Ambient Temperature

Storage Conditions

The lyophilized protein is stable for at least one year from date of receipt at -70Â°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2Â° - 8Â°C for one month, or at -20Â°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Appearance

Lyophilized Powder

Formulation

Lyophilized from a 0.2 Î¼m filtered solution in PBS

CAS Number

9000-83-3

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