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Recombinant Human Neuritin

Neuritin is known to play an important role in promoting neuronal survival, differentiation, function, and repair. The expression of Neuritin can be induced in response to neural activity and neurotrophins. NRN1 promotes neurite outgrowth and arborization, especially branching of neuritic processes in primary hippocampal and cortical cells, suggesting its role in promoting neuritogenesis. Overexpression of NRN1 may be associated with astrocytoma progression. Recombinant human Neuritin is a covalently disulfide-linked homodimer, consisting of two 9.8 kDa polypeptide monomers.

Product Specifications

Gene Name

NRN1

Gene Aliases

NRN1, CPG15, NRN

Gene ID

51299

Accession Number

Q9NPD7

Organism

Human

Source

E. coli

Concentration

<1.0 EU/μg of recombinant protein as determined by the LAL method.

Purity

>95% as determined by SDS-PAGE

Solubility

A quick spin of the vial followed by reconstitution in sterile distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Function

N.A.

Molecular Weight

10.4

Shipping Conditions

Ambient Temperature

Storage Conditions

The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Appearance

Lyophilized Powder

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4

CAS Number

9000-83-3

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