Recombinant Human MMP2

MMP-2 belongs to a family of endoproteases which need calcium and zinc in order to exert their catalytic capability (extracellular matrix remodeling). The elevated expression of these enzymes has been linked to many degenerative disorders, such as arthritis, cancer metastasis and skeletal growth-plate disorders. It has been shown that MMP-2 associates with many connective tissue cells as well as neutrophils, macrophages and monocytes.

Product Specifications

CAS Number

9000-83-3

Gene Name

MMP2

Gene Aliases

MMP-2, 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, TBE-1<br/>Recombinant Human Matrix Metalloproteinase-2 (MMP2)

Gene ID

4313

Accession Number

P08253

Organism

Human

Source

E. coli

Concentration

< 1.0 EU/μg of recombinant protein as determined by the LAL method.

Purity

>95% as determined by SDS-PAGE

Solubility

N.A.

Function

The ED(50) was determined by the dose-dependent proliferation of immortalized human pulmonary fibroblasts cells and was found to be <0.05ng/mL.

Molecular Weight

Shipping Conditions

Ambient Temperature

Storage Conditions

The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.