GNE-886
GNE-886 (Compound 21) is a potent and selective inhibitor of Cat eye syndrome chromosome region candidate 2 bromodomain (CECR2) (BRD) with an IC50 value of 0.016 µM and an EC50 value of 370 nM. GNE-886 also inhibits BRD9 with an IC50 value of 1.6 µM[1].
Product Specifications
CAS Number
[2101957-05-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gne-886.html
Purity
99.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CN(CC=C)C(C2=C1C=CN2)=O)N(C3CCN(C4=NC=NC(C5=CC=CC(OC)=C5)=C4)CC3)C
Molecular Formula
C28H30N6O3
Molecular Weight
498.58
Precautions
H302, H315, H319, H335
References & Citations
[1]Crawford TD, et al. GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2) . ACS Med Chem Lett. 2017 Jun 1;8 (7) :737-741.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
127133-ML650 100 µL
GALNT13 (KIAA1918, Polypeptide N-acetylgalactosaminyltransferase 13, Polypeptide GalNAc Transferase 13, Protein-UDP Acetylgalactosaminyltransferase 13, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13, FLJ16031, FLJ41157, H_NH0187G20.1, MGC119459, MGC119461) (MaxLight 650)
Ask
View Details 