Recombinant Human Maspin (SerpinB5)
Mammary serine protease inhibitor (Maspin) is a non-inhibitory tumor suppressor serpin that is encoded by the SERPINB5 gene. Playing an important role in embryonic development in cell adhesion, Maspin has the ability to suppress the growth, invasion, and metastasis of breast and lung tumors. However, Maspin does not exhibit any serine protease inhibitor activity since it does not undergo the conformational transition from stressed to relaxed found in typical serpins. It is expressed in normal breast and prostatic epithelial cells, but downregulated in most breast carcinoma.
Product Specifications
CAS Number
9000-83-3
Gene Name
SERPINB5
Gene Aliases
Maspin, Peptidase inhibitor 5
Gene ID
5268
Accession Number
P36952
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method
Purity
>95% as determined by SDS-PAGE
Function
The ED(50) was determined by the dose-dependent proliferation of MDA-MB-468 cells and was found to be <0.05ng/mL.
Molecular Weight
42.3
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
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