Recombinant Human M-CSF (CSF1)
M-CSF is produced by monocytes, granulocytes, endothelial cells, and fibroblasts. After cell activation, B cells and T cells and also a number of tumor cell lines are capable also of synthesizing this factor. M-CSF has been found to be synthesized by uterine epithelial cells in vivo. The M-CSF receptor is identical with the proto-oncogene fms. It has been renamed CD115. The receptor is a transmembrane protein with an extracellular ligand-binding domain of 512 amino acids, an intramembrane domain of 25 amino acids, and a cytoplasmic domain of 435 amino acids encoding a tyrosine kinase. Human M-CSF is active in mouse and rat cells. The murine factor is active in rat cells but inactive in human cells. M-CSF is a specific factor in that the proliferation inducing activity is more or less restricted to the macrophage lineage. M-CSF is a potent stimulator of functional activities of monocytes.
Product Specifications
CAS Number
9000-83-3
Gene Name
CSF1
Gene Aliases
Macrophage colony-stimulating factor 1, CSF-1, M-CSF, MCSF, Lanimostim <br/>Recombinant Human Macrophage Colony Stimulating Factor (CSF1)
Gene ID
1435
Accession Number
P09603
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method
Purity
>95% as determined by SDS-PAGE
Solubility
Function
The ED50 as determined by the dose-dependent stimulation of the proliferation of M-NFS-60 cells was found to be < 1.0 ng/mL
Molecular Weight
18.5
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 μm filtered solution in Tris and NaCl (pH 7.5)
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