Recombinant Human KGF (FGF7)
KGF is a member of the family of fibroblast growth factors, it is secreted in large amounts by fibroblast-like stromal cells in epithelial tissues. The KGF receptor encodes a tyrosine kinase and is a member of the family of receptors binding aFGF and bFGF. Binding of KGF to its receptor is competed by aFGF and bFGF. Although KGF is a potent specific mitogen for many epithelial cells it is not so for fibroblasts and endothelial cells. KGF is thought to play an important role in the paracrine growth control of normal epithelial cells. KGF stimulates the proliferation of primary and secondary human keratinocytes to the same extent as EGF.
Product Specifications
Gene Name
FGF7
Gene Aliases
KGF, Fibroblast Growth Factor-7, HBGF-7, Heparin-binding growth factor 7<br/>Recombinant Human Keratinocyte Growth Factor (FGF7)
Gene ID
2252
Accession Number
P21781
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method
Purity
>95% as determined by SDS-PAGE
Solubility
Function
The ED50 as determined by the dose-dependent proliferation of 3T3 cells was found to be less than 0.5 ng/mL.
Molecular Weight
19
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS (pH 7.0)
CAS Number
9000-83-3
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