Recombinant Human IP-10 (CXCL10)
IP-10 shows homology to PF-4 (platelet factor-4) and belongs to the family of chemotactic cytokines known as chemokines. The receptor for IP-10 is CXCR3. IP-10 has been shown to bind to the virus-encoded viroceptor M3. The expression of IP-10 from a variety of cells, including monocytes, endothelial cells, keratinocytes, and fibroblasts, is induced by IFN-gamma and TNF-alpha. Human neutrophils produce IP-10 in response to IFN- gamma in combination with either TNF-alpha or bacterial lipopolysaccharides. IP-10 probably also plays a role in regulation of the growth of immature hematopoietic progenitor cells. It has been shown to suppress in vitro colony formation of highly enriched cells expressing the cell surface marker CD34 in the presence of SCF, GM-CSF, or SCF and EPO, but not in their absence with the exception of SCF.
Product Specifications
Gene Name
CXCL10
Gene Aliases
CXCL10, C-X-C motif chemokine 10, 10 kDa interferon gamma-induced protein, Gamma-IP10, Small-inducible cytokine B10, IP10
Gene ID
3627
Accession Number
P02778
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
Function
Determined by its ability to chemoattract human T-Lymphocytes using a concentration of 10-50 ng/mL.
Molecular Weight
9
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Recombinant IP-10/CXCL10 was lyophilized from 0.2 μm filtered PBS solution, pH 7.0.
CAS Number
9000-83-3
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