Recombinant Human IL21
IL-21 stimulates proliferation of B cell stimulated by crosslinking of the CD40 antigen. It inhibits proliferation stimulated by IL-4 plus anti-IgM. IL-21 augments stimulation of the proliferation of naive CD45RA(+) but not memory CD45R0(+) T cells mediated by engagement of CD3. IL-21 stimulates the proliferation of bone marrow progenitor cells and the expression of the natural killer cell marker CD56 in the presence of IL-15. The Interleukin-21 receptor is closely related to human IL-2 beta receptor. The receptor contains a WSXWS motif in the extracellular region, typical of type 1 cytokine receptors. The receptor is expressed on natural killer cells, T cells, and B cell line. The functional signaling complex activates Janus kinases JAK1, JAK3, and the STAT proteins STAT1, and STAT3.
Product Specifications
CAS Number
9000-83-3
Gene Name
IL21
Gene Aliases
IL-21, Za11<br/>Recombinant Human Interleukin-21 (IL21)
Gene ID
59067
Accession Number
Q9HBE4
Organism
Human
Source
E. coli
Concentration
< 1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
Function
The ED(50) was determined by the dose-dependent proliferation of activated B Cells.
Molecular Weight
15
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Recombinant Interleukin-21 was lyophilized from a 0.2 μm filtered PBS solution pH 7.5.
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