Recombinant Human IL2
A helical bundle of 4 α-helices, IL2 is an immunoregulatory cytokine that is expressed by CD4+/CD8+ T cells, γδ T cells, B cells, eosinophils and dendritic cells. IL2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. While Human IL2 shares 56% and 66% amino acid sequence identity with mouse and rat IL2, respectively only human and mouse IL2 exhibit cross-species activity. Characteristically, IL2 exerts both autocrine and paracrine activity on T cells. In a regulatory role, IL2 is important for the development, survival, and function of regulatory T cells, it enhances Fas-mediated activation-induced cell death, and it inhibits the development of inflammatory Th17 cells. Recombinant Human IL2 is a non-glycosylated polypeptide that contains one intrachain disulfide bond.
Product Specifications
Gene Name
IL2
Gene Aliases
IL-2, T-cell growth factor, TCGF, Aldesleukin, INN=Aldesleukin<br/>Recombinant Human Interleukin-2 (IL2)
Gene ID
3558
Accession Number
P60568
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
Function
The ED50 as determined by the dose dependent proliferation of human T cells was found to be less than 0.5 ng/mL
Molecular Weight
15
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2μm filtered solution in Tris and NaCL (pH 8.0)
CAS Number
9000-83-3
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