Recombinant Human IL17D

Interleukin 17D is a disulfide-linked homodimer belonging to the IL-17 family of proinflammatory cytokines. Members belonging to this family share conserved features of cysteine-knot structures but differ in their N-terminal regions. The T-helper cell produced IL17 family is inducible by IL15 and IL23, and IL17D induces expression of endothelial IL6, IL8, and GM-CSF, and inhibits hemopoiesis of myeloid progenitor cells.

Product Specifications

CAS Number

9000-83-3

Gene Name

IL17D

Gene Aliases

Interleukin-27

Gene ID

53342

Accession Number

Q8TAD2

Organism

Human

Source

E. coli

Concentration

< 1.0 EU/μg of recombinant protein as determined by the LAL method.

Purity

>95% as determined by SDS-PAGE

Solubility

Reconstitute in sterile 4mM HCl at 100µg/mL (containing at least 0.1% human or bovine serum albumin)

Function

The ED50 is 7.5-37.5 ng/mL as determined by its binding ability in a functional ELISA (at a concentration of 1 µg/mL)

Molecular Weight

20.5

Shipping Conditions

Ambient Temperature

Storage Conditions

The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.