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Recombinant Human IL17A

The founding member of the IL17 family of cytokines, IL17A plays an important role in antimicrobial and chronic inflammation. All the six IL17 cytokines (IL17A-F) share a cystine knot fold and are secreted as homodimers. Mature human IL17A shares 60% amino acid sequence identity with rat and mouse IL17A. IL17 cytokines bind to two receptors; IL17RA and IL17RC that together form a heterodimer. The receptor heterodimer is preferred by IL17 ligands, and thus, either IL17RA or IL17RC knockouts completely abolish IL17 signalling. Recombinant human IL17A is a non-glycosylated, 32 kDa disulfide-linked homodimer.

Product Specifications

CAS Number

9000-83-3

Gene Name

IL17A

Gene Aliases

IL-17, CTLA-8, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8<br/>Recombinant Human Interleukin-17A (IL17A)

Gene ID

3605

Accession Number

Q16552

Organism

Human

Source

E. coli

Concentration

< 1.0 EU/μg of recombinant protein as determined by the LAL method.

Purity

>95% as determined by SDS-PAGE

Solubility

A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Function

The ED(50), as determined by the dose-dependent proliferation of induction of IL6 in primary human foreskin fibroblasts was found to be approximately 2.0 ng/mL, corresponding to a specific activity of &gt; 5.0 x 10^5 units/mg

Molecular Weight

16

Shipping Conditions

Ambient Temperature

Storage Conditions

The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Appearance

Lyophilized Powder

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS (pH 7.5)

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