Recombinant Human IL17A
The founding member of the IL17 family of cytokines, IL17A plays an important role in antimicrobial and chronic inflammation. All the six IL17 cytokines (IL17A-F) share a cystine knot fold and are secreted as homodimers. Mature human IL17A shares 60% amino acid sequence identity with rat and mouse IL17A. IL17 cytokines bind to two receptors; IL17RA and IL17RC that together form a heterodimer. The receptor heterodimer is preferred by IL17 ligands, and thus, either IL17RA or IL17RC knockouts completely abolish IL17 signalling. Recombinant human IL17A is a non-glycosylated, 32 kDa disulfide-linked homodimer.
Product Specifications
CAS Number
9000-83-3
Gene Name
IL17A
Gene Aliases
IL-17, CTLA-8, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8<br/>Recombinant Human Interleukin-17A (IL17A)
Gene ID
3605
Accession Number
Q16552
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method
Purity
>95% as determined by SDS-PAGE
Solubility
Function
Molecular Weight
16
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS (pH 7.5)
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