Recombinant Human IFNG
IFNG is produced mainly by T cells and natural killer cells activated by antigens, mitogens or alloantigens and by lymphocytes expressing the surface antigens CD4 and CD8. Receptors for IFNG are expressed on all types of human cells with the exception of mature erythrocytes. IFNG-receptor complexes are rapidly internalized by endocytosis. In addition to its antiviral and antiparasitic activities, IFNG also inhibits the proliferation of a number of normal and transformed cells. The growth inhibitory activities of IFNG are in fact, more pronounced than those of the other interferons. However, the main biological activity of IFNG appears to be immunomodulatory in contrast to the other interferons that are mainly antiviral.
Product Specifications
CAS Number
9000-83-3
Gene Name
IFNG
Gene Aliases
IFN-gamma, Immune interferon, IFNG, type II interferon, T cell interferon, MAF<br/>Recombinant Human Interferon-Gamma (IFNG)
Gene ID
3458
Accession Number
P01579
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method
Purity
>95% as determined by SDS-PAGE
Solubility
A quick spin of the vial followed by reconstitution in 20mM acetic acid not less than 0.1 mg/mL.
Function
The ED50 was found to be ≤ 0.5ng/ml as determined by its ability to induce dose dependent proliferation in vascular smooth muscle cells.
Molecular Weight
17
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 μm filtered solution in sodium phosphate and NaCl (pH 8.0)
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