Recombinant Human Galectin-3 (LGALS3)

Gal-3 interacts, via its lectin domain, with glycoproteins and glycolipids on the surface of animal cells. It has been shown that nuclear Gal3 can modulate gene expression while cytosolic Gal3 can inhibit apoptosis and participate in exocytosis. Gal-3 is generally expressed by the epithelial cells of many tissues as well as by inflammatory cells. An increased level of Gal-3 expression may lead to some lymphomas, as well as thyroid and hepatic carcinomas while the down-regulation has been associated with breast and colon cancer.

Product Specifications

CAS Number

9000-83-3

Gene Name

LGALS3

Gene Aliases

IgE-Binding Protein, Gal-3, 35 kDa lectin, Carbohydrate-binding protein 35, CBP 35, Galactose-specific lectin 3, Galactoside-binding protein, GALBP, L-31, Laminin-binding protein, Lectin L-29, Mac-2 antigen

Gene ID

3958

Accession Number

P17931

Organism

Human

Source

E. coli

Concentration

< 1.0 EU/μg of recombinant protein as determined by the LAL method.

Purity

>95% as determined by SDS-PAGE

Solubility

Reconstitute at 50 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin

Function

Measured by its ability to agglutinate human red blood cells. The ED(50) for this effect is typically 3-10 µg/mL.

Molecular Weight

26.1

Shipping Conditions

Ambient Temperature

Storage Conditions

The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.