Recombinant Human Galectin-3 (LGALS3)
Gal-3 interacts, via its lectin domain, with glycoproteins and glycolipids on the surface of animal cells. It has been shown that nuclear Gal3 can modulate gene expression while cytosolic Gal3 can inhibit apoptosis and participate in exocytosis. Gal-3 is generally expressed by the epithelial cells of many tissues as well as by inflammatory cells. An increased level of Gal-3 expression may lead to some lymphomas, as well as thyroid and hepatic carcinomas while the down-regulation has been associated with breast and colon cancer.
Product Specifications
Gene Name
LGALS3
Gene Aliases
Gene ID
3958
Accession Number
P17931
Organism
Human
Source
E. coli
Concentration
< 1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
Reconstitute at 50 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin
Function
Measured by its ability to agglutinate human red blood cells. The ED(50) for this effect is typically 3-10 µg/mL.
Molecular Weight
26.1
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS.
CAS Number
9000-83-3
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