Recombinant Human Galectin-1 (LGALS1)
Galectin-1 is a member of the galectin family, and binds B-galactosidase moieties on glycoproteins or glycolipids. Galectins are primarily involved in modulation of cell-cell and cell-matrix interactions. Galectin-1 acts as a negative regulator of immunity, promoting immune suppression and lessening the inflammatory response. Galectin-1 binds CD45, CD3 and CD4, resulting in the inhibition of CD45 phosphatase dependant dephosphorylation of lyn kinase, as well as a number of other immune related receptors. Due to its function as a negative regulator of the immune response, and role inducing apoptosis in activated Th1 and Th17 cells, it is commonly found upregulated around malignant tumours. It has also been implicated as having a role in the development of immune tolerance during pregnancy, and is highly expressed at the maternal-fetal interface. As a dimer it down-regulates neutrophils by inducing exposure of phosphatidylserine, thereby marking the cell for apoptosis. It shares approximately 88% and 90% sequence similarity with mouse and rat galectin-1, respectively. Recombinant Human Galectin-1 is a 14.9kDa protein.
Product Specifications
CAS Number
9000-83-3
Gene Name
LGALS1
Gene Aliases
Gene ID
3956
Accession Number
P09382
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method
Purity
>95% as determined by SDS-PAGE
Solubility
Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin
Function
Measured by its ability to agglutinate human red blood cells. The ED(50) for this effect is typically 0.53 µg/mL.
Molecular Weight
14.9
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS and 2-ME with BSA as a carrier protein.
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Mouse IgM Kappa Isotype Control Monoclonal Clone MM30 FITC 100ug
