What is the catalog number for Recombinant Human FGF23?

The catalog number for Recombinant Human FGF23 is Z100985.

What sizes are available for Recombinant Human FGF23?

Recombinant Human FGF23 is available in the following size(s): 20 µg.

Is Recombinant Human FGF23 in stock?

Recombinant Human FGF23 is currently made to order / not held in immediate stock. Contact us for lead time.

Recombinant Human FGF23

FGF-23 is a protein of ∼30 kDa that is proteolytically processed to generate smaller N-terminal (18 kDa) and C-terminal (12 kDa) fragments. The N-terminal fragment of FGF-23 contains the FGF receptor (FGFR)-binding domain. In vivo studies using synthetic peptides have indicated that neither of the processed N-terminal or C-terminal fragments of FGF-23 can influence serum phosphate levels. FGF-23 can decrease the activity of NaPi-2a and NaPi-2c cotransporters to reduce renal phosphate reabsorption and thereby can increase urinary phosphate excretion. Similarly, FGF-23 can suppress the expression of 1-alpha-hydroxylase to reduce the production of the active vitamin D metabolite 1,25(OH)2D. Moreover, FGF-23 can also induce 24- hydroxylase, which degrades 1,25(OH)2D

Product Specifications

CAS Number

9000-83-3

Gene Name

FGF23

Gene Aliases

FGF-23, Phosphatonin, Tumor-derived hypophosphatemia-inducing factor, HYPF<br/>Recombinant Human Fibroblast Growth Factor 23 (FGF23)

Gene ID

8074

Accession Number

Q9GZV9

Organism

Human

Source

E. coli

Concentration

<1.0 EU/μg of recombinant protein as determined by the LAL method.

Purity

>95% as determined by SDS-PAGE

Solubility

A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Function

The ED(50) was determined by the dose-dependent proliferation of mouse 3T3 cells expressing FGF receptors, and was found to be < 0.3 ug/mL, corresponding to a specific activity of 3.0 x 10^4 units/mg.

Molecular Weight

23

Shipping Conditions

Ambient Temperature

Storage Conditions

The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.