Recombinant Human FGF21

FGF-21 is a secreted growth factor of the FGF family, classified as an FGF-19 subfamily member. Proteins of the FGF family are known to play a central role with respect to both prenatal and postnatal growth and development, and regeneration of a variety of tissues by promoting cellular proliferation and differentiation. In the presence of beta Klotho (protein cofactor), FGF-21 signals via the FGFR receptors to stimulate insulin independent glucose uptake by adipocytes.

Product Specifications

CAS Number

9000-83-3

Gene Name

FGF21

Gene Aliases

FGF-21<br/>Recombinant Human Fibroblast Growth Factor 21 (FGF21)

Gene ID

26291

Accession Number

Q9NSA1

Organism

Human

Source

E. coli

Concentration

<1.0 EU/μg of recombinant protein as determined by the LAL method.

Purity

>95% as determined by SDS-PAGE

Solubility

A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Function

The bioactivity was determined in a NIH/3T3 cell proliferation assay with an ED50 <1ng/ml.

Molecular Weight

19.7

Shipping Conditions

Ambient Temperature

Storage Conditions

The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2°- 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.