Recombinant Human FGF18
Human FGF18 is a member of the FGF family, a group of related proteins having broad mitogenic and cell survival activity. Members of this family have key roles in prenatal development, as well as postnatal growth and tissue regeneration. FGF18 promotes chondrogenesis, through interaction with FGFR3. It has been demonstrated to cause an increase in cartilage in a murine osteoarthritis model. It has also been implicated in the proliferation of tissues, notably the liver and small intestine. FGF18 also signals through FGFR 1c, 2c and 4. Recombinant Human FGF18 is a 20.4 kDa heparin binding growth factor.
Product Specifications
Gene Name
FGF18
Gene Aliases
Fibroblast Growth Factor-18, zFGF5
Gene ID
8817
Accession Number
O76093
Organism
Human
Source
E. coli
Concentration
< 1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
Function
The bioactivity was determined in a 3T3 cell proliferation assay. The ED50 was in the range of 0.05 - 0.1 ng/ml.
Molecular Weight
20.4
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 μm filtered solution in phosphate buffer, NaCl, KCl and EDTA (pH 7.5)
CAS Number
9000-83-3
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