Recombinant Human CXCL14 (BRAK)
Chemokine (CXC motif) ligand 14, also known as breast and kidney-expressed chemokine (BRAK), is a CXC chemokine that is a potent chemoattractant for neutrophils but not for T-cells, B-cells, monocytes or granulocytes. Mature CXCL14 has many conserved features of the CXC family and is 30% homologous to the MIP-α and MIP-β sequences, but differs in that it has an additional five amino acid sequence in between the third and fourth cysteines and a short N-terminus. It is usually highly expressed near its fibroblast source and in epidermal fibroblasts and keratinocytes of skin, but is absent from cancer cells.
Product Specifications
CAS Number
9000-83-3
Gene Name
CXCL14
Gene Aliases
Chemokine BRAK, MIP-2G, Small-inducible cytokine B14
Gene ID
9547
Accession Number
O95715
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method
Purity
>95% as determined by SDS-PAGE
Solubility
Function
The ED50 is 0.25-1.25 ng/mL as determined by its ability to induce calcium flux in activated monocytes.
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2µm filtered solution containing 20mM Tris pH 8.5 and 1M NaCl
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