Recombinant Human CXCL12 (SDF-1 beta)
A member of the CXC chemokine family, CXCL12 is strongly chemotactic for T-, B-, and cancer cells. Known to exert its effects mainly through binding to the CXCR4 receptor, CXCL12 plays an important role in morphogenesis, angiogenesis, and cancer metastasis. CXCL12 also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for CXCL12. Encoded by a single gene, SDF-1 alpha (89 amino acids) and SDF-1 beta (93 amino acids) are derivatives of an alternative splicing event. SDF-1α and SDF-1β have identical amino acid sequences, differing only, by the presence of four extra amino acids at the C-terminus of the β form. SDF-1 beta is constitutively expressed by stromal cells.
Product Specifications
Gene Name
CXCL12
Gene Aliases
Gene ID
6387
Accession Number
P48061
Organism
Human
Source
E. coli
Concentration
< 1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
Function
Determined by its ability to chemoattract human peripheral T cells activated with PHA and IL-2 using a concentration range of 5.0-40 ng/mL
Molecular Weight
8.5
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 μm filtered solution in sodium phosphate and NaCl (pH 7.5)
CAS Number
9000-83-3
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