Recombinant Human CTACK (CCL27)
CCL27 is a CC family chemokine which is expressed in epithelial cells and known to be up-regulated by inflammatory stimuli/wounded skin. CCL27 partakes in inflammation and wound healing – by selectively attracting and directing CLA+ T cells into the skin, and inducing the migration of keratinocyte precursors from bone marrow to the skin. High levels of this chemokine in human serum though, have been linked to the severity of various diseases, one being atopic dermatitis.
Product Specifications
Gene Name
CCL27
Gene Aliases
Gene ID
10850
Accession Number
Q9Y4X3
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin
Function
Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR10. The ED50 for this effect is typically 0.1-0.4 µg/mL.
Molecular Weight
10.4
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
CAS Number
9000-83-3
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