Recombinant Human CTACK (CCL27)

CCL27 is a CC family chemokine which is expressed in epithelial cells and known to be up-regulated by inflammatory stimuli/wounded skin. CCL27 partakes in inflammation and wound healing – by selectively attracting and directing CLA+ T cells into the skin, and inducing the migration of keratinocyte precursors from bone marrow to the skin. High levels of this chemokine in human serum though, have been linked to the severity of various diseases, one being atopic dermatitis.

Product Specifications

CAS Number

9000-83-3

Gene Name

CCL27

Gene Aliases

CTACK , C-C motif chemokine 27, CC chemokine ILC, Skinkine, ESkine, IL-11 R-alpha-locus chemokine, Small-inducible cytokine A27<br/>Recombinant Human Cutaneous T-cell-Attracting Chemokine (CCL27)

Gene ID

10850

Accession Number

Q9Y4X3

Organism

Human

Source

E. coli

Concentration

<1.0 EU/μg of recombinant protein as determined by the LAL method.

Purity

>95% as determined by SDS-PAGE

Solubility

Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin

Function

Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR10. The ED50 for this effect is typically 0.1-0.4 µg/mL.

Molecular Weight

10.4

Shipping Conditions

Ambient Temperature

Storage Conditions

The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.