Recombinant Human CD40 Ligand (CD40LG)
CD40LG protein is expressed on all B lymphocytes during various stages of development, activated T cells and monocytes, follicular dendritic cells, thymic epithelial cells, and various carcinoma cell lines. It is expressed on most mature B cell malignancies and on some early B cell acute lymphocytic leukemias. Human CD40LG has been found to be the receptor for a protein involved in an X-linked immunodeficiency syndrome. Based on its homology with other members of the TNF ligand protein superfamily, CD40LG is also referred to also as TNFSF5. The soluble form of CD40LG is generated by the intracellular proteolytic processing of the full length CD40LG. Recombinant Human CD40LG is a 17 kDa protein that represents the soluble segment of full length CD40LG and encompasses the receptor binding TNF-like domain.
Product Specifications
Gene Name
CD40LG
Gene Aliases
Gene ID
959
Accession Number
P29965
Organism
Human
Source
E. coli
Concentration
< 1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
Function
The ED50 as determined by dose-dependent proliferation of acute myeloid leukemia was found to be <5 ng/ml
Molecular Weight
16
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS (pH 7.0)
CAS Number
9000-83-3
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