Recombinant Human Cardiotrophin-1 (CT-1)
Cardiotrophin-1 is a pleiotrophic cytokine and is a member of the IL-6 cytokine family that also includes IL6, IL11, LIF, OSM, CLC and IL31.Full length human CT-1 shares a 79% amino acid sequence identity with murinic CT-1 and both lack a canonical signal sequence. Cardiotrophin-1 interacts with the leukemia inhibitory factor receptor (LIFR) heterodimer and the glycoprotein 130 subunit (gp130) and has the ability to induce cardiac myocyte hypertrophy. It is highly expressed in various skeletal muscles and cardiac tissue, as well as the colon, ovary and prostate, liver, and pancreas, while lower expression levels are found in the lungs, kidney, pancreas, testis, and small intestine.
Product Specifications
CAS Number
9000-83-3
Gene Name
CTF1
Gene Aliases
Recombinant Human Cardiotrophin-1, CTF1, CT1, CT-1
Gene ID
1489
Accession Number
Q16619
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method
Purity
>95% as determined by SDS-PAGE
Solubility
Reconstitute in sterile HCl at 100µg/mL (containing at least 0.1% human or bovine serum albumin)
Function
ED50 is ≤ 1.0 ng/mL as determined by the dose-dependent TF-1 cell proliferation
Molecular Weight
21
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 µm filtered solution in PBS
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