What is the catalog number for Recombinant Human Beta-Defensin 2 (DEFB4A)?

The catalog number for Recombinant Human Beta-Defensin 2 (DEFB4A) is Z100039.

What sizes are available for Recombinant Human Beta-Defensin 2 (DEFB4A)?

Recombinant Human Beta-Defensin 2 (DEFB4A) is available in the following size(s): 1 mg.

Is Recombinant Human Beta-Defensin 2 (DEFB4A) in stock?

Recombinant Human Beta-Defensin 2 (DEFB4A) is currently made to order / not held in immediate stock. Contact us for lead time.

Recombinant Human Beta-Defensin 2 (DEFB4A)

Defensins are a large family of peptides of which two groups exist in mammals: alpha defensins and beta defensins - which are distinguishable by the spacing and connectivity of the conserved cysteine residues within the mature peptides. It is thought that the function of defensins in the eradication of pathogens from the host system is to insert themselves into the bacterial membrane under the influence of membrane potential, in doing so forms channels which lead to leakage of cytoplasmic molecules and cell death. Unlike hBD-1, this second peptide, human beta-defensin-2 (hBD-2), is regulated at a transcriptional level in response to contact with microorganisms, and is highly effective in killing the gram negative bacteria. Its expression is also upregulated by the cytokine tumor necrosis factor-alpha.

Product Specifications

CAS Number

9000-83-3

Gene Name

DEFB4A

Gene Aliases

Beta-defensin 4A, BD-2, hBD-2, Defensin, beta 2, Skin-antimicrobial peptide 1, SAP1, DEFB102, DEFB2, DEFB4

Gene ID

1673

Accession Number

O15263

Organism

Human

Source

E. coli

Concentration

<1.0 EU/μg of recombinant protein as determined by the LAL method.

Purity

>95% as determined by SDS-PAGE

Solubility

A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Function

The ED(50) was Determined by its ability to chemoattract immature human dendritic cells using a concentration range of 1-50 ng/mL.

Molecular Weight

4

Shipping Conditions

Ambient Temperature

Storage Conditions

The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.