Recombinant Human BCA-1 (CXCL13)
The homeostatic chemokine CXCL13 is constitutively expressed in secondary lymphoid tissue and initiates lymphoid neogenesis when expressed aberrantly in mice. CXCL13 has also been detected in chronic inflammation associated with human lymphoid neogenesis, suggesting a pathogenic role. Follicular dendritic cells (FDCs) are generally considered to be the major source of CXCL13 both in normal and aberrant lymphoid tissue. CXCL13 has been the exclusive ligand for CXCR5, which initiates chemotaxis toward an increasing gradient in vitro and to B cell zones in lymph nodes that express CXCL13. More recently, CXCR5 expression has also been shown in DN T cells in mice, a subset of CD4 follicular Th cells, and some tonsillar CD4+ and CD25+ Tregs in humans.
Product Specifications
CAS Number
9000-83-3
Gene Name
CXCL13
Gene Aliases
BLC, B cell Attracting Chemokine-1, CXCL13, C-X-C motif chemokine 13, BCA1
Gene ID
10563
Accession Number
Q53X90
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
Function
Determined by its ability to chemoattract human CXCR5 transfected mouse BaF3 B cells, the ED(50) is less than 20 ng/mL.
Molecular Weight
10
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS,100 mM NaCl, pH 7.5
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