Recombinant Human AREG
Amphiregulin is a trans-membrane protein whose protease mediated digestion of the extracellular domain enables release of mature AR. Amphiregulin works to stimulate the proliferation of some animal keratinocyles, epithelial cells and fibroblasts. It has been shown that the mRNA expression of amphiregulin can be detected in numerous carcinoma cell lines and the epithelial cells of various human tissues, including colon, stomach, breast, ovary and kidney.
Product Specifications
CAS Number
9000-83-3
Gene Name
AREG
Gene Aliases
AR, Colorectum cell-derived growth factor, CRDGF<br/>Recombinant Human Amphiregulin (AREG)
Gene ID
374
Accession Number
P15514
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin
Function
Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED(50) for this effect is typically 515 ng/mL.
Molecular Weight
11.5
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein
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