Recombinant Human AIMP1
EMAP-II is activated during apoptosis by cleavage of pro-EMAP through caspase 8 and enhances the recruitment of inflammatory cells by its chemotactic properties. Besides its chemotactic effect on inflammatory cells, EMAP-II increases the adhesiveness of coronary artery smooth muscle cells (CASMC) for monocytes. EMAP-II also has anti-angiogenic properties, which are explained by its pro-apoptotic effect on endothelial cells.
Product Specifications
CAS Number
9000-83-3
Gene Name
AIMP1
Gene Aliases
Gene ID
9255
Accession Number
Q12904
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
Function
The ED(50) was determined by apoptotic effect on MCF-7 cells using a concentration of 10-50 ng/mL.
Molecular Weight
18
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 μm filtered 20 mM PBS,130 mM NaCl solution pH 7.5
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