Recombinant Human Activin A (INHBA)
Part of the TGF-β family, inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic, pituitary and gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development and bone growth depending on their subunit composition. Activin A is a disulfide linked homodimer (two beta-A chains) that binds to the two forms of activin receptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B). The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. Recombinant Human Activin A is a homodimeric, non-glycosylated protein that has a molecular weight of 26 kDa.
Product Specifications
Gene Name
INHBA
Gene Aliases
Activin beta-A chain, Inhibin beta-A chain, Erythroid differentiation protein, INHBA, FSH releasing protein
Gene ID
3624
Accession Number
P08476
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method
Purity
>95% as determined by SDS-PAGE
Solubility
Function
The ED(50) as determined by the ability to induce cytotoxicity of MPC-11 cells was found to be 1-1.5 ng/ml
Molecular Weight
13
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a concentrated protein solution containing 0.02% TFA
CAS Number
9000-83-3
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