Rentosertib
Rentosertib (INS018 055) (compound 112) is the orally active TNIK and MAP4K4 inhibitor with IC50 values of 12-120, 12-120 nM, respectively[1].
Product Specifications
CAS Number
2828567-39-9
Product Name Alternative
INS018_055; TNIK&MAP4K4-IN-2
UNSPSC
12352005
Target
Cadherin; Interleukin Related; MAP4K; TGF-beta/Smad
Type
Reference compound
Related Pathways
Cytoskeleton; Immunology/Inflammation; MAPK/ERK Pathway; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tnik-map4k4-in-2.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CN=C(C2=C(C3=CC=C(C=C3)F)N=CN2C(C)C)N1)NC4=CC=C(N5CCN(CC5)C)C=C4
Molecular Formula
C27H30FN7O
Molecular Weight
487.57
References & Citations
[1]Aleksandrs Zavoronkovs, et al. Analogs for the treatment of disease. WO2022179528A1.|[2]Ren F, et al. A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models. Nat Biotechnol. 2025 Jan;43 (1) :63-75.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP4K4/HGK
Available Sizes
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