5,15-Diphenylporphyrin

5,15-Diphenylporphyrin (5,15-DPP) is an inhibitor of the oncogenic transcription factor STAT3. 5,15-Diphenylporphyrin specifically binds to the SH2 domain of STAT3, blocking the pTyr-SH2 interaction, thereby inhibiting the dimerization, nuclear translocation and DNA binding activity of STAT3, and ultimately inhibiting the expression of cancer cell-related genes. 5,15-Diphenylporphyrin can be used in research fields related to the development of anticancer drugs[1][2].

Product Specifications

CAS Number

[22112-89-6]

Product Name Alternative

5,15-DPP

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/5-15-diphenylporphyrin.html

Purity

95.0

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C1(/C2=CC=CC=C2)=C3C=CC(/C=C4C=C/C(N/4)=C(C5=CC=CC=C5)/C(C=C/6)=NC6=C/C7=CC=C1N7)=N/3

Molecular Formula

C32H22N4

Molecular Weight

462.54

Precautions

H302, H315, H319, H335

References & Citations

[1]Uehara Y, et al. Novel high-throughput screening system for identifying STAT3-SH2 antagonists. Biochem Biophys Res Commun. 2009;380 (3) :627-631. |[2]Xiang F, et al. Coverage-induced chiral transition of Co (II) -5, 15-diphenylporphyrin self-assemblies on Cu (111) [J]. The Journal of Physical Chemistry C, 2022, 126 (15) : 6745-6752.