CRT0066101
CRT0066101 is a potent and orally active PKD inhibitor with IC50 values of 1 nM, 2.5 nM and 2 nM for PKD1, PKD2, and PKD3, respectively[1]. CRT0066101 is also a potent PIM2 inhibitor with an IC50 of ~135.7 nM. CRT0066101 exhibits anti-inflammatory activity in mice LPS -induced lung injury models, and has anticancer effects[1][2][3].
Product Specifications
CAS Number
956123-34-5
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Apoptosis; Pim; PKD
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/crt0066101.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N[C@H](CC)CNC1=NC(C2=C(O)C=CC(C3=CN(C)N=C3)=C2)=NC=C1
Molecular Formula
C18H22N6O
Molecular Weight
338.41
Precautions
H302, H312, H332
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
PIM2; PKD1; PKD2; PKD3
Available Sizes
Frequently Asked Questions
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