Tripolin B
Tripolin B is an ATP-competitive Aurora kinase inhibitor with IC50 values of 2.5 µM and 6 µM for Aurora A and Aurora B kinases, respectively. Tripolin B does not inhibit Aurora kinase in cells[1].
Product Specifications
CAS Number
186611-44-9
UNSPSC
12352005
Target
Aurora Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tripolin-b.html
Smiles
O=C1NC2=C(C=CC=C2)/C1=C/C3=CN=CN3
Molecular Formula
C12H9N3O
Molecular Weight
211.22
References & Citations
[1]Iliana A Kesisova, et al. Tripolin A, a novel small-molecule inhibitor of aurora A kinase, reveals new regulation of HURP's distribution on microtubules. PLoS One. 2013;8 (3) :e58485.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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